作者:Tian, HY (Tian, Huaiyu)[ 1 ] ; Zhou, S (Zhou, Sen)[ 2,3 ] ; Dong, L (Dong, Lu)[ 4 ] ; Van Boeckel, TP (Van Boeckel, Thomas P.)[ 5 ] ; Cui, YJ (Cui, Yujun)[ 6 ] ; Wu, YR (Wu, Yarong)[ 6 ] ; Cazelles, B (Cazelles, Bernard)[ 7,8,9,10 ] ; Huang, SQ (Huang, Shanqian)[ 1 ] ; Yang, RF (Yang, Ruifu)[ 6 ] ; Grenfell, BT (Grenfell, Bryan T.)[ 5,11 ] 更多内容

　　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

　　卷: 112  期: 1  页: 172-177

　　DOI: 10.1073/pnas.1405216112

　　出版年: JAN 6 2015

　　摘要

　　The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to     reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.

　　通讯作者地址: Grenfell, BT (通讯作者)

　　Princeton Univ, Dept Ecol & Evolut Biol, Princeton, NJ 08544 USA.

　　地址:

　　[ 1 ] Beijing Normal Univ, Coll Global Change & Earth Syst Sci, State Key Lab Remote Sensing Sci, Beijing 100875, Peoples R China

　　[ 2 ] Tsinghua Univ, Ctr Earth Syst Sci, Key Lab Earth Syst Modelling, Minist Educ, Beijing 100084, Peoples R China

　　[ 3 ] Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China

　　[ 4 ] Beijing Normal Univ, Coll Life Sci, Key Lab Biodivers & Ecol Engn, Minist Educ, Beijing 100875, Peoples R China

　　[ 5 ] Princeton Univ, Dept Ecol & Evolut Biol, Princeton, NJ 08544 USA

　　[ 6 ] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

　　[ 7 ] Univ Paris 06, CNRS, UMR 7625, F-75230 Paris 05, France

　　[ 8 ] Ecole Normale Super, F-75230 Paris 05, France

　　[ 9 ] Inst Rech Dev, Unite Modelisat Mathemat & Informat Syst Complexe, Unite Mixte Int 209, F-93142 Bondy, France

　　[ 10 ] Univ Paris 06, F-93142 Bondy, France

　　[ 11 ] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

　　[ 12 ] Univ Utah, Dept Geog, Salt Lake City, UT 84112 USA